Given that the proto-oncogene c-Myc binding E boxes (CACGTG) match the hypoxia response element consensus sequence (A/GCGT), which results in a similar pattern of gene regulation between HIFs and c-Myc, and that the promoter also contains putative c-Myc binding E boxes in its ?340 bp region, we reasonably speculated that might be a target gene of c-Myc
Given that the proto-oncogene c-Myc binding E boxes (CACGTG) match the hypoxia response element consensus sequence (A/GCGT), which results in…