In 2018, 78 patients were alive, 25 had died, and 25 had lost contact. glucocorticoid dose were higher in the group of patients who died. Laboratorial features related to mortality were creatinine, hemoglobin, erythrocyte sedimentation ratio, and C-reactive protein (CRP). Logistic regression analysis showed that high VDI, creatinine levels, and CRP levels were independent factors associated with mortality. Survival was significantly decreased in patients with renal impairment. This is the first study to use this approach performed in a Brazilian populace and it showed that damage index, renal impairment, and CRP levels were associated with mortality in a miscegenated populace with AAV. or MannCWhitney assessments. Odds ratios (OR) were estimated with the respective 95% confidence intervals for each characteristic for mortality using unadjusted logistic regression. The joint model was adjusted to explain the mortality of patients according to the characteristics of the last outpatient assessment using multiple logistic regression. The variables that showed statistical significance in the bivariate analyzes and that present clinical relevance with the disease and its worst prognosis and all variables included in the final model (full model) were maintained. Each item of the VDI was tested separately with the mortality of patients to explore which ones most influenced K-Ras G12C-IN-3 their final end result using chi-squared test or Fisher exact test. The analyzes were performed using the IBM-SPSS for Windows version 20.0 software and tabulated using the Microsoft-Excel 2003 software. The tests were performed with a 5% significance level. The protocol was approved by the Ethics Committee of the Clinics Hospital of University or college of Sao Paulo, School of Medicine. According to the Ethics Committee, the present study waives consent declaration from your patients, once there is no intervention related to them or data disclosure (Ethics Committee opinion no. 2,903,237, September 19, 2020). 3.?Results One hundred and twenty-eight patients were initially K-Ras G12C-IN-3 included. One hundred and one of these patients experienced GPA (78.9%), 21 experienced EGPA (16.4%), and 6 had MPA K-Ras G12C-IN-3 (4.6%). In 2018, 78 (60.9%) of the patients were alive, 25 (19.5%) had died, and 25 (19.5%) had lost contact and could not be assessed via telephone, and therefore were excluded from your analysis. The mean time of follow up was 10.77 (6.13) years for the living patients until 2018 and 8.44 (5.96) years for K-Ras G12C-IN-3 the group of patients who died (test. BVAS?=?Birmingham vasculitis activity score, CRP?=?C-reactive protein, ESR?=?erythrocyte sedimentation ratio, VDI?=?vasculitis damage index. ?Chi-square’s test. ??Student’s test. Logistic regression analysis showed that high VDI scores (OR 1.43, CI 95% 1.08C1.89, em P /em ?=?.013), creatinine levels (OR 1.27, CI 95% 1.03C1.56, em P /em ?=?.024), and CRP levels (OR 1.05, CI 95% 1.00C1.09, em P /em ?=?.031) were indie factors associated with mortality (Table ?(Table22). Table 2 Logistic regression analysis of the mortality predictors. thead 95% CIVariableORLowerUpper em P /em /thead BVAS0.980.811.19.851VDI1.431.08s1.89.013Creatinine, mg/dL1.271.031.56.024CRP, mg/L1.051.001.09.031Prednisone dose, mg/d1.020.991.06.226 Open in a separate window Multivariate logistic regression (full model). BVAS?=?Birmingham vasculitis activity score, CRP?=?C-reactive protein, VDI?=?vasculitis damage index. Of the 64 items in the VDI, 8 were significantly different between the 2 groups: significant muscle mass atrophy or weakness, estimated/measured glomerular filtration rate (GFR) 50%, proteinuria 0.5?g/24?h, end-stage renal disease, chronic breathlessness, malignancy, visual impairment/diplopia, and oral ulcers (Fig. ?(Fig.1).1). A logistic regression was made with the 8 items of the VDI that were considered statistically different in the first analysis. In the logistic regression, 4 Rabbit polyclonal to MAPT of the 8 items remained different between the groups: visual impairment/diplopia (OR 6.22, CI 95% 1.27C30.41, em P /em ?=?.024), chronic breathlessness (OR 6.03, CI 95% 1.10C32.84, em P /em ?=?.038), estimated/measured GFR (by CKD-EPI equation), 50% (OR 6.08, CI 95% 1.08C33.94, em P /em ?=?.04), and malignancy (OR 9.27, CI 95% 1.66C51.66, em P /em ?=?.01). Open in a separate window Physique 1 Comparison of the vasculitis damage index (VDI) most scored items between the groups. BP?=?blood pressure, GFR?=?glomerular filtration ratio. A survival analysis was performed comparing the patients who experienced kidney dysfunction, which was defined as a GFR 50% (same definition used in the VDI), with those who did not. The duration of the disease was calculated from the time of the diagnosis until 2018, the year of the study, for the living patients or until the time of the death for the patients who died. This analysis showed that survival was significantly decreased among patients with AAV and renal impairment (11.98??1.58?years vs 21.53??1.05?years; em P /em ? ?.001) (Fig. ?(Fig.22). Open in a separate.